Fig 7.

Effect of MI-S treatment on mortality of infected mice after HSV-2 vaginal challenge. Mice (n = 10) were intravaginally treated as follows: Group 1, infected, untreated; Group 7, MI-S treatment at 20 mg/ml (233.86 μM), once, 20 min before infection; Group 8, vehicle-only treatment, once, 20 min before infection; Group 2, MI-S treatment at 10 mg/ml (116.93 μM), 3 times daily after infection, for 8 days; Group 4, vehicle-only treatment, 3 times daily after infection, for 8 days. Survival was monitored for up to 9 days after virus infection. (A) Pretreatment; (B) postinfection treatment. The data for the different groups were compared by the log rank (Mantel-Cox) test; P values of <0.05 were considered statistically significant.