Table 1.
Spectrum of anti-HSV activity of Agaricus brasiliensis sulfated polysaccharide (MI-S)
| Virus strain | EC50a (μg/ml) (μM) |
|
|---|---|---|
| Simultaneous treatment | Postinfection treatment | |
| HSV-1 CJ360 | 15.76 ± 3.84 (0.18 ± 0.04) | 17.79 ± 1.18 (0.21 ± 0.01) |
| HSV-1 CJ311 | 2.35 ± 0.83 (0.03 ± 0.01) | 29.98 ± 2.54 (0.35 ± 0.03) |
| HSV-1 CJ394 | 5.67 ± 0.77 (0.07 ± 0.01) | 25.97 ± 0.93 (0.30 ± 0.01) |
| HSV-1 KOS | 17.27 ± 3.95 (0.20 ± 0.05) | 31.75 ± 3.35 (0.37 ± 0.04) |
| HSV-1 OD4 | 10.41 ± 1.96 (0.12 ± 0.02) | 37.53 ± 5.34 (0.44 ± 0.06) |
| HSV-2 333 | 4.73 ± 0.04 (0.06 ± 0.0004) | 13.32 ± 2.68 (0.16 ± 0.03) |
a
EC50, 50% inhibitory concentration. Values represent the means ± SD of three independent experiments.