Table 5.
fTMIC relationship to ABE for ceftaroline at 96 h
| ABE at 96 h |
fTMIC (%)a |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MSSA |
MRSA |
All S. aureus strains | |||||||||
| Strain SMD 44100 (0.12) | Strain SMD 44099 (0.12) | Strain SMD 43450 (0.25) | Strain SMD 43448 (1.0) | All MSSA strains | Strain SMD 42690 (0.25) | Strain SMD 43454 (1.0) | Strain SMD 33815 (1.5) | Strain SMD 43456 (2.0) | All MRSA strains | ||
| Static | 71.1 | 38.9 | 43.0 | 38.0 | 47.8 ± 15.8 | 38.0 | 36.0 | 52.3 | 26.2 | 38.1 ± 10.8 | 42.9 ± 13.5 |
| −1-log-unit drop | 76.6 | 48.3 | 45.0 | 39.0 | 52.2 ± 16.7 | 39.0 | 37.0 | 56.4 | 27.5 | 40.0 ± 12.0 | 46.1 ± 15.0 |
| −2-log-unit drop | 81.2 | 58.4 | 48.0 | 41.0 | 57.2 ± 17.6 | 40.0 | 38.0 | 59.7 | 28.5 | 41.6 ± 13.1 | 49.3 ± 16.6 |
| −3-log-unit drop | 91.3 | 71.1 | 51.0 | 42.0 | 63.8 ± 22.0 | 41.0 | 39.0 | 64.4 | 30.2 | 43.7 ± 14.6 | 53.7 ± 20.4 |
| −4-log-unit drop | 62.0 | 46.0 | 86.6 | 34.9 | 57.3 ± 22.4 (n = 4) | ||||||
a
Data in parentheses are MICs (in micrograms per milliliter).