Table 6.
Changes in ceftaroline population profiles in S. aureus at 48 h and 96 h of drug exposure
| Time of drug exposure and TMIC (%) | No. of expts | No. of expts with growth on 2× MIC plates | Count on 2× MIC plates (log CFU/ml) | No. of expts with growth on 4× MIC plates | Count on 4× MIC plates (log CFU/ml) |
|---|---|---|---|---|---|
| At 48 h | |||||
| ≥80 | 15 | 0 | <2 | 0 | <2 |
| 70–79 | 6 | 0 | <2 | 0 | <2 |
| 50–69 | 8 | 0 | <2 | 0 | <2 |
| 40–49 | 5 | 1 | 2.7 | 1 | 2.1 |
| 30–39 | 8 | 2 | 3.9 | 0 | <2 |
| 25–29 | 8 | 4 | 4.4 ± 2.0 | 0 | <2 |
| 20–24 | 8 | 5 | 4.3 ± 1.8 | 0 | <2 |
| 15–19 | 7 | 4 | 5.2 ± 2.1 | 0 | <2 |
| 10–14 | 7 | 2 | 4.7 | 0 | <2 |
| At 96 h | |||||
| ≥80 | 15 | 0 | <2 | 0 | <2 |
| 70–79 | 6 | 1 | 2.5 | 0 | <2 |
| 50–69 | 8 | 1 | 2.5 | 0 | <2 |
| 40–49 | 5 | 3 | 3.4 ± 1.6 | 1 | 2.1 |
| 30–39 | 8 | 5 | 7.1 ± 1.0 | 4 | 4.8 ± 2.3 |
| 25–29 | 8 | 6 | 5.5 ± 1.4 | 4 | 4.6 ± 2.3 |
| 20–24 | 8 | 6 | 6.1 ± 1.7 | 4 | 4.3 ± 1.6 |
| 15–19 | 7 | 5 | 5.6 ± 2.6 | 3 | 3.9 ± 1.7 |
| 10–14 | 7 | 5 | 6.4 ± 2.3 | 4 | 3.7 ± 1.4 |