Table 1.
SEVI does not have direct antimicrobial activity as determined by MICa
| Organism | Strain | MIC (μg/ml) |
|
|---|---|---|---|
| SEVI fibrils | Peptide monomer (PAP248-286) | ||
| S. aureus (MSSA) | ATCC 29213 | >128 | >128 |
| S. aureus (MRSA) | ATCC 43300 | >128 | >128 |
| S. aureus (MSSA) | UAMS-1 | >128 | >128 |
| S. epidermidis | ATCC 12228 | 128 | 128 |
| E. faecalis | ATCC 29212 | 64 | >128 |
| E. coli | ATCC 27853 | >128 | >128 |
| E. coli | CFT-073 | >128 | >128 |
| P. aeruginosa | ATCC 27853 | >128 | >128 |
| N. gonorrhoeaeb | FA1090 | >128 | >128 |
a
Growth inhibition was determined by visual inspection after overnight incubation and confirmed by CFU counts or by conducting CFU counts after 2 h of culturing.
b
Instead of an MIC assay, a pseudo-MBC assay was performed for N. gonorrhoeae.