Figure 1.

Comparison of reactive lymphocyte markers. (A) Between HIV-infected (positive) and uninfected (negative) patients. AR-DLBCL contains markedly reduced helper (CD4⁺) and regulatory (FOXP3⁺) T cells, whereas evaluation of cytotoxic markers showed that it is characterized by a disproportional enrichment in activated (granzyme-positive) tumor-infiltrating cytotoxic T cells. (B) Between pre-HAART and post-HAART HIV-infected patients. Although loss of infiltrating CD4⁺ T cells is attenuated after the use of HAART, their number remains significantly lower than in sporadic DLBCL.