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. 2012 Apr 11;27(8):3305–3314. doi: 10.1093/ndt/gfr806

Table 2.

Study characteristics

Primary author Year Single/multicenter Location Kidney Txp'sa A primary aim to study biomarkers? Sample medium Biomarkersb Quality scorec
Hollmen et al. [51] 2011 Single Europe 95d Yes Urine NGAL 10
Moers et al. [47] 2010 Multi Europe 306 Yes Perfusate GST, LDH, AST, Ala-AP, NAG and HFABP 9
Robert et al. [50] 2010 Multi Europe 48d Yes Urine Lactate, acetate, alanine, citrate, dimethylamine, dimethylglycine, succinate, trimethylamine and TMAO 8
Nijboer et al. [49] 2009 Single Europe 20d Yes Urine KIM-1 8
de Vries et al. [46] 2006 Single Europe 231 Yes Perfusate Redox-active Fe/GST/LDH 9
Asher et al. [41] 2005 Single Europe 88 No Perfusate GST 3
Gok et al. [26] 2003 Single Europe 74 Yes Perfusate GST, Ala-AP and HFABP 7
Kosieradzki et al. [27] 2003 Single Europe 50 Yes Perfusate MDA and TAS 7
Kosieradzki et al. [38] 2002 Single Europe 234 Yes Perfusate GST, lactate and LDH 8
Polyak et al. [48] 2000 Single US 650 Yes Perfusate Na+, Cl−, K+, Ca++, pH 8
Shoskes et al. [36] 2000 Single US 29d Yes Urine TEAC and IsoP 4
Sarvary et al. [35] 2000 Single Europe 61d Yes Urine GST 6
Zivna et al. [37] 1999 Single Europe 22d Yes Urine IL-2, IL-6, IL-8 and TNF-α 6
Danielewicz et al. [43] 1997 Single Europe 86 Yes Perfusate Lactate, LDH, Na+, K+, pH, pO2/pCO2, osmolarity 7
Kootstra et al. [42] 1997 Single Europe 71 Yes Perfusate GST and LDH 4
Daemen et al. [29] 1997 Single Europe 46 Yes Perfusate GST and LDH 6
Cho et al. [30] 1981 Multi US 24 Yes Perfusate GST (ligandin) 6
Newman and Shenton [28] 1981 Single Europe 23 Yes Perfusate LDH, lactate, pH 7
Sy et al. [24] 1980 Single US 50 Yes Perfusate pO2/pCO2, pH, osmolarity, occasional electrolytes 3
Feinfeld et al. [31] 1978 Single US 13 Yes Perfusate GST (ligandin) 7
Horpacsy et al. [32] 1978 Single Europe 81 Yes Perfusate LDH, lactate, pH 5
Burleson et al. [33] 1978 Single US 63 No Perfusate Lactate 3
Anderson et al. [44] 1977 Single US 100 No Perfusate LDH and AST 5
Modgill et al. [45] 1977 Single Europe 32 Yes Perfusate LDH, lactate, pH 7
Stephenson et al. [39] 1975 Single Europe 52 No Perfusate LDH, AST, lactate, glucose, K+ 4
Johnson et al. [34] 1974 Multi US/Europe 114 Yes Perfusate Lactate 4
Johnson et al. [23] 1973 Single Europe 26 Yes Perfusate LDH, lactate, pH, pO2/pCO2 6
Kiser et al. [40] 1972 Multi US 130 No Perfusate LDH 3
Sterling et al. [25] 1972 Multi US 34 No Perfusate LDH, acid phosphatase, electrolytes 3

aTxp's, transplants.

bBiomarker abbreviations (Ala-AP, alanine aminopeptidase; Fe, iron; IsoP, 8-iso-prostaglandin F2α; TMAO, trimethylamine-N-oxide; TNF-α, tumor necrosis factor-α).

cQuality score is a modified version of the STARD criteria and is fully detailed in Table 1, Score ≥9 is ‘good’ quality, 7 and 8 are ‘fair’ quality and ≤6 is ‘poor’ quality.

dNumber of deceased donors (urine studies).