Table 3.
Studies of specific biomarkers from deceased-donor kidney perfusate and their associations with allograft outcomes
| Outcomesa |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| DGF |
PNF |
GF |
||||||||
| Perfusate biomarkerb | Studies | Kidney Txp'sc | Significant association | Studies | Significant association | Studies | Significant association | Studies | Significant association | |
| Traditional markers | Flow | 12 | 1680 | 4 | 8 | 4 | 2 | 0 | 3 | 0 |
| Resistance | 6 | 1318 | 3 | 5 | 3 | 2 | 0 | 1 | 0 | |
| Perfusion pressure | 5 | 365 | 2 | 3 | 2 | 1 | 0 | 0 | 0 | |
| Chemical markers | LDH | 12 | 1320 | 7 | 9 | 6 | 3 | 1 | 3 | 1 |
| pH | 7 | 948 | 1 | 5 | 1 | 1 | 0 | 2 | 0 | |
| GST | 7 | 777 | 5 | 6 | 4 | 3 | 2 | 1 | 0 | |
| Lactate | 7 | 599 | 2 | 5 | 2 | 0 | 0 | 3 | 0 | |
| Electrolytes | 5 | 872 | 1 | 3 | 1 | 1 | 0 | 1 | 0 | |
| AST | 3 | 458 | 2 | 2 | 2 | 1 | 0 | 1 | 0 | |
| pO2/pCO2 | 3 | 162 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | |
| Ala-AP | 2 | 380 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | |
| HFABP | 2 | 380 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | |
| Osmolarity | 2 | 136 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | |
| NAG | 1 | 306 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | |
| Redox-active Fe | 1 | 231 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | |
| Glucose | 1 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |
| MDA | 1 | 50 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | |
| TAS | 1 | 50 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | |
| Acid phosphatase | 1 | 34 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
aOutcomes [DGF (as defined by each study, typically temporary post-transplant dialysis); GF (as defined by each study, typically recipient serum creatinine concentration or creatinine clearance); PNF (as defined by each study, typically continued/permanent post-transplant dialysis)].
bBiomarker abbreviations (Ala-AP, alanine aminopeptidase; Fe, iron).
cTxp's, transplants.