Fig. 8.

Temporal dependency of intraperitoneal (2.40 mmol/kg) 2-ACP (A) or equimolar NAC (B) on oral APAP- (500 mg/kg) induced lethality. Hepatoprotectants were administered 20 minutes before (–20), 20 minutes after (+20), or 60 minutes after (+60) APAP intoxication. Kaplan-Meier survival curves illustrate the cumulative percent daily lethality in the APAP-alone, APAP/NAC, and APAP/ACP groups (n = 15 mice/group). Joining line indicates statistically significant differences in treatment groups at **P < 0.01 and *P < 0.05 levels of significance.