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(A) Effects of oral 2-ACP (2.40 mmol/kg) or equimolar NAC on oral APAP- (500 mg/kg) induced lethality. (B) Dose dependency of oral NAC (0.80–2.40 mmol/kg) on oral APAP- (500 mg/kg) induced lethality. Kaplan-Meier survival curves illustrate the cumulative percent daily lethality in the APAP-alone, APAP/NAC, and APAP/ACP groups (n = 15 mice/group). Joining line indicates statistically significant differences in treatment groups at ***P < 0.001 and *P < 0.05 levels of significance.
