TABLE 1.
SKF93959 competition binding experiments against various G protein–coupled receptors
Ki values were derived from radioligand binding competition curves generated against each of the above targets (n = 2) as described in Materials and Methods.
| Target | SKF83959 Ki | S.E.M. |
|---|---|---|
| nM | ||
| 5-HT1A | 1648.0 | 352.3 |
| 5-HT2A | 246.6 | 32.1 |
| 5-HT2B | 405.0 | 145.1 |
| 5-HT2C | 32.8 | 13.3 |
| 5-HT5A | 277.8 | 141.8 |
| 5-HT6 | 546.0 | 56.0 |
| α1A | 1290.5 | 154.5 |
| α1D | 1115.5 | 232.4 |
| α2A | 323.7 | 120.6 |
| α2B | 163.1 | 17.8 |
| α2C | 31.1 | 7.6 |
| D1R | 1.7 | 0.8 |
| D2R | 567.0 | 150.0 |
| D3R | 1018.3 | 109.8 |
| D4R | 1975.7 | 756.4 |
| D5R | 4.0 | 0.1 |
| H2 | 1699.3 | 640.3 |
| M4 | 5238.5 | 1985.5 |
| M5 | 3484.0 | 114.0 |
| SERT | 365.6 | 79.2 |
α1A, α-adrenergic receptor subtype 1A; α1D, α-adrenergic receptor subtype 1D; α2A, α-adrenergic receptor subtype 2A; α2B, α-adrenergic receptor subtype 2B; α2C, α-adrenergic receptor subtype 2C; 5-HT1A, serotonergic receptor subtype 1A; 5-HT2A, serotonergic receptor subtype 2A; 5-HT2B, serotonergic receptor subtype 2B; 5-HT2C, serotonergic receptor subtype 2C; 5-HT5A, serotonergic receptor subtype 5A; 5-HT6, serotonergic receptor subtype 6; M4, muscarinic receptor subtype 4; M5, muscarinic receptor subtype 5; SERT, serotonin transporter.