Table 4.
Topics with eight or more overlapping meta-analyses*
| Topic | No of meta-analyses | Journal (No of studies included) | Comments |
|---|---|---|---|
| Chemoprevention of colorectal neoplasia | 13 | 1 Nutr Hosp 2012 (n=7); 2 Clin Ther 2010 (n=6); 3 Health Technol Assess 2010 (n=44)†; 4 Pak J Pharm Sci 2010 (n=4); 5 Aliment Pharmacol Ther 2010 (n=6); 6 Med Oncol (2010 (n=5); 7 J Natl Cancer Inst 2009 (n=4); 8 Colorectal Dis 2009 (n=3); 9 CDSR 2008 (n=2); 10 Zhonghua Yi Xue Za Zhi 2007 (n=6); 11 Aliment Pharmacol Ther 2006 (n=8); 12 Am J Gastroenterol 2005 (n=3); 13 Lancet 2004 (n=14) | Index meta-analysis evaluated NSAIDs, folic acid, calcium, vitamin D, and antioxidants including vitamin E. Other meta-analyses evaluated one of these interventions, thus they all partially overlap with index meta-analysis |
| Pharmacotherapy in fibromyalgia | 12 | 1 CNS Drugs 2012 (n=35); 2 CDSR 2012 (n=5); 3 Rheumatology 2011 (n=19); 4 J Clin Pharm Ther 2010 (n=3); 5 BMC Musculoskelet Disord 2010 (n=4); 6 J Pain 2010 (n=8)†; 7 Rheumatology 2010 (n=4); 8 CDSR 2009 (n=3); 9 CDSR 2009 (n=5); 10 Pain 2009 (n=5); 11 Clin Rheumatol 2009 (n=5); 12 J Womens Health 2007 (n=2) | Index meta-analysis evaluated duloxetine, milnacipran, and pregabalin. Meta-analyses 1, 3, and 6 were published by same team and presented as updates. Meta-analysis 2 evaluated milnacipran only. Meta-analyses 4, 5, 7, and 10 evaluated pregabalin. 11 and 12 evaluated duloxetine. 8 and 9 are meta-analyses of duloxetine and pregabalin, respectively, for different pain syndromes, including fibromyalgia |
| Statins for prevention of atrial fibrillation after cardiac surgery | 11 | 1 Br J Clin Pharmacol 2012 (n=8); 2 CDSR 2012 (n=8); 3 Arch Surg 2012 (n=9); 4 Ann Med 2011 (n=8); 5 J Am Coll Cardiol 2010 (n=6); 6 J Thorac Cardiovasc Surg 2010 (n=6)†; 7 Tex Heart Inst J 2009 (n=10); 8 J Thorac Cardiovasc Surg 2009 (n=13); 9 Ann Thorac Surg 2009 (n=2); 10 Eur Heart J 2008 (n=7); 11 J Am Coll Cardiol 2008 (n=3) | All meta-analyses considered any statin and any dosing. Studies 1 and 3 included also non-surgery trials and non-cardiac surgery trials, respectively (in separate analyses). Meta-analysis 11 analyzed cardiac surgery trials along with trial pertaining to acute coronary syndromes For additional details see table 5 |
| Antiepileptics for refractory epilepsy | 8 | 1 Epilepsia 2011 (n=62); 2 Can J Neurol Sci 2011 (n=8); 3 Epilepsia 2010 (n=54)†; 4 CDSR 2005 (n=4); 5 Epilepsia 2003 (n=3); 6 Epilepsia 1997 (n=29); 7 Epilepsia 1997 (n=5); 8 BMJ 1996 (n=20) | Studies 1, 3, 6, and 8 evaluated several different antiepileptics each, whereas 2 and 5 evaluated levetiracetam, 4 evaluated zonisamide, and 7 evaluated topiramate |
CDSR=Cochrane Database of Systematic Reviews.
*In some topics not all meta-analyses are overlapping with each other, but they overlap to a lesser or greater degree with the index meta-analysis.
†Index meta-analysis.