Table 1.

U-69593-stimulate [³⁵S]GTPγS autoradiography in the brains of rats following of rats given 14 days chronic escalating-dose binge cocaine or saline, 1 day or 14 days withdrawn from cocaine or saline. CPu caudate putamen; AcC, Accumbens core; AcS, Accumbens shell; LH, lateral hypothalamus; BLA basolateral amygdala; SNc, substantia nigra compacta; SNr, substatia nigra reticulata VTA, ventral tegmental area. The values represent means ± SEM of percent of activation from basal value (n=7).

	Stimulation [35S]GTPγS binding (%)
Regions	Chronic Saline	Chronic Cocaine	Saline 1 day withdrawal	Cocaine 1 day withdrawal	Saline 14 days withdrawal	Cocaine 14 days withdrawal
CPu	32.4 ± 1.3	35.6 ± 3.5	40.8 ± 2.3	42.3 ± 2.0	37.2 ± 2.6	32.1 ± 2.2
AcC	31.3 ± 1.8	38.3 ± 1.4	35.2 ± 1.9	44.4 ± 3.0	37.8 ± 1.6	36.3 ± 5.0
AcS	34.4 ± 1.4	42.0 ± 2.2	36.2 ± 3.3	35.8 ± 2.8	36.6 ± 2.6	38.9 ± 4.7
LH	37.8 ± 2.2	43.4 ± 2.9	38.5 ± 2.8	36.1 ± 3.2	35.9 ± 3.6	30.5 ± 2.1
BLA	35.4 ± 2.0	31.1 ± 1.4	38.2 ± 2.6	35.1 ± 3.1	30.0 ± 2.9	27.4 ± 1.7
SNr	32.4 ± 1.5	36.0 ± 1.9	37.7 ± 3.7	38.6 ± 4.8	36.2 ± 1.8	37.9 ± 2.3
SNc	28.5 ± 1.8	30.7 ± 1.4	31.9 ± 1.9	41.3 ± 5.5	37.8 ± 1.7	34.1 ± 3.4
VTA	28.0 ± 1.8	32.8 ± 2.2	27.5 ± 1.9	42.22 ± 4.1*	32.8 ± 1.8	33.6 ± 1.4

^*P<0.01.