Table 1.
Immunological and inflammatory markers [median (IQR)] by baseline HIV-1 RNA
| Marker | Totala | Baseline HIV-1 RNA (copies/mL) |
|||
|---|---|---|---|---|---|
| ≤100 000b | >100 000c | P value* | |||
| CD4+/HLA-DR+/CD38+ % | baseline | 11 (7, 20) | 9 (5, 15) | 18 (9, 23) | <0.001 |
| week 24 | 5 (3, 9) | 5 (2, 6) | 8 (5, 12) | <0.001 | |
| week 24 Δ | −6 (−11, −2)# | −4 (−9, −2)# | −8 (−13, −3)# | 0.017 | |
| week 48 | 3 (2, 7) | 3 (2, 5) | 5 (3, 8) | 0.003 | |
| week 48 Δ | −7 (−14, −4)# | −5 (−11, −3)# | −11 (−16, −5)# | 0.006 | |
| CD8+/HLA-DR+/CD38+ % | baseline | 39 (29, 51) | 36 (26, 50) | 46 (33, 55) | 0.014 |
| week 24 | 16 (9, 23) | 11 (8, 19) | 18 (10, 27) | 0.007 | |
| week 24 Δ | −22 (−32, −13)# | −20 (−30, −13)# | −25 (−34, −14)# | 0.374 | |
| week 48 | 10 (7, 16) | 9 (6, 13) | 11 (9, 21) | 0.031 | |
| week 48 Δ | −27 (−37, −16)# | −24 (−33, −16)# | −30 (−39, −20)# | 0.084 | |
| IL-6 (pg/mL) | baseline | 1.38 (0.81, 2.37) | 1.11 (0.70, 2.01) | 1.73 (1.25, 3.15) | 0.003 |
| week 24 | 1.17 (0.65, 1.76) | 1.06 (0.65, 1.67) | 1.19 (0.66, 1.91) | 0.848 | |
| week 24 Δ | −0.32 (−0.97, 0.18)# | −0.14 (−0.71, 0.28)# | −0.61 (−2.08, −0.02)# | 0.040 | |
| week 48 | 1.17 (0.63, 1.66) | 1.13 (0.53, 1.66) | 1.21 (0.65, 1.69) | 0.526 | |
| week 48 Δ | −0.37 (−0.96, 0.22)# | −0.22 (−0.69, 0.26)# | −0.42 (−1.64, 0.12)# | 0.299 | |
| LPS (pg/mL) | baseline | 21 (10, 35) | 21 (10, 33) | 20 (10, 38) | 0.899 |
| week 24 | 26 (12, 35) | 26 (10, 35) | 25 (12, 36) | 0.800 | |
| week 24 Δ | 0 (−9, 12) | 1 (−8, 13) | 0 (−10, 10) | 0.557 | |
| week 48 | 22 (6, 34) | 16 (5, 34) | 25 (12, 33) | 0.478 | |
| week 48 Δ | −1 (−12, 8) | −3 (−14, 5) | 4 (−11, 12) | 0.176 | |
| IP-10 (pg/mL) | baseline | 517 (349, 929) | 425 (282, 673) | 690 (459, 1184) | <0.001 |
| week 24 | 180 (140, 326) | 175 (136, 332) | 194 (144, 280) | 0.642 | |
| week 24 Δ | −296 (−555, −144)# | −185 (−395, −98)# | −481 (−968, −260)# | <0.001 | |
| week 48 | 172 (123, 249) | 173 (122, 267) | 166 (123, 246) | 0.737 | |
| week 48 Δ | −344 (−649, −141)# | −255 (−447, −75)# | −522 (−999, −304)# | <0.001 | |
| sCD14 (×106 pg/mL) | baseline | 2.42 (1.96, 3.08) | 2.11 (1.71, 2.90) | 2.75 (2.16, 3.16) | 0.002 |
| week 24 | 2.03 (1.63, 2.37) | 2.02 (1.57, 2.28) | 2.06 (1.69, 2.63) | 0.377 | |
| week 24 Δ | −0.46 (−0.97, 0.08)# | −0.21 (−0.93, 0.12)# | −0.71 (−1.09, −0.25)# | 0.046 | |
| week 48 | 1.98 (1.65, 2.43) | 2.00 (1.62, 2.41) | 1.95 (1.68, 2.56) | 0.815 | |
| week 48 Δ | −0.41 (−1.01, 0.06)# | −0.22 (−0.70, 0.12)# | −0.71 (−1.24, −0.07)# | 0.021 | |
| D-dimer (ng/mL) | baseline | 202 (111, 362) | 160 (105, 332) | 266 (140, 513) | 0.035 |
| week 24 | 136 (73, 258) | 118 (70, 255) | 147 (82, 260) | 0.331 | |
| week 24 Δ | −45 (−130, −12)# | −34 (−113, −2)# | −64 (−170, −25)# | 0.036 | |
| week 48 | 130 (78, 251) | 144 (85, 255) | 129 (74, 232) | 0.566 | |
| week 48 Δ | −62 (−148, −12)# | −47 (−100, 11)# | −83 (−212, −39)# | 0.013 | |
aDepending on assay result availability, n ranges from 96 to 107.
bDepending on assay result availability, n ranges from 52 to 59.
cDepending on assay result availability, n ranges from 44 to 48.
*Exact Wilcoxon rank sum test comparing baseline HIV-1 RNA ≤100 000 and >100 000 copies/mL.
#Exact Wilcoxon signed rank test comparing changes from baseline: P < 0.05.