TABLE 1.
Comparison of laboratory and hemodynamic data between normal and high uric acid groups in patients with idiopathic pulmonary arterial hypertension
|
Uric acid levels
|
P | ||
|---|---|---|---|
| Normal (n=34) | High (n=52) | ||
| Age, years | 35.7±10.1 | 36.4±11.9 | NS |
| Sex, male/female, n/n | 11/23 | 19/33 | NS |
| Serum creatinine, μmol/L | 65.7±10.1 | 100.2±18.4 | <0.001 |
| Serum uric nitrogen, μmol/L | 4.2±1.1 | 8.3±2.6 | 0.002 |
| Blood pH | 7.40±0.33 | 7.42±0.34 | NS |
| Blood oxygen pressure, mmHg | 72±14 | 68±16 | NS |
| Blood CO2, mmHg | 28±7 | 27±6 | NS |
| Blood oxygen saturation, % | 87±10 | 85±9 | NS |
| Heart rate, beats/min | 74±15 | 88±16 | 0.017 |
| Systolic blood pressure, mmHg | 118±16 | 116±17 | NS |
| Diastolic blood pressure, mmHg | 71±10 | 74±11 | NS |
| Systolic pulmonary pressure, mmHg | 68±12 | 79±11 | 0.012 |
| MPAP, mmHg | 48±9 | 58±12 | 0.013 |
| Left ventricular ejection fraction, % | 45.9±4.1 | 42.3±3.9 | 0.04 |
| Right ventricular ejection fraction, % | 49.5±5.0 | 41.2±4.3 | 0.02 |
| New York Heart Association class | 2.0±0.3 | 2.7±0.5 | 0.04 |
Data presented as mean ± SD unless otherwise indicated. CO2 Carbon dioxide; MPAP Mean pulmonary arterial pressure; NS Not significant