Table 1.

Relevant signal transduction inhibitors clinical trials in MDS

Family	Molecule	Trials
P38 MAP kinase inhibitors	SCIO-469, ARRY- 614	NCT00113893 NCT01496495
Activin and TGF- β receptor ligand trap	ACE- 011 & ACE 536	NCT 01736683 NCT01432717
Multikinase Inhibitor (Plk/Akt/PI3)	Onconova-01910	NCT00906334
P13K/mTOR inhibitors	Deferolimus, Temsirolimus, Everolimus,	NCT00819546 NCT00086125 NCT00809185 NCT01111448
P13K/AKT Inhibitors	Perifosine	NCT00301938
EGF Receptor Inhibitor	Erlotinib	NCT01085838 NCT00977548
GSTPI-1 inhibitor	Ezatiostat	NCT00700206 NCT01422486 NCT01459159
Farnesyl Transferase Inhibitors	Tipifarnib, Lonafarnib	NCT00005845 NCT00045396 NCT00050154 NCT00034684 NCT00005967
Mek Inhibitor	GSK1120212	NCT00920140