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. 2013 Jul 19;8(7):e68638. doi: 10.1371/journal.pone.0068638

Figure 3. GM6001 is significantly more effective than other metallopeptidase inhibitors at preventing SP degradation and conversion of SP to SP1–9.

Figure 3

A) Utilizing the MEROPS and Allen Brain Map databases a number of candidate metallopeptidases in the nervous system that are capable of cleaving SP to produce SP1–9 are identified. Inhibitors against these peptidases were then used in lysates to evaluate their affect on SP degradation and SP1–9 production. B) The matrix metalloprotease (MMP) inhibitor GM6001 was the most effective compound at preventing SP degradation. C) GM6001 is also the best inhibitor of SP1–9 production. (Statistical significance calculated by a Student's t-test; p-value <0.05, *; p-value <0.01, **; p-value <0.001, ***, N = 4).