Table 1. Demographics for Birmingham and Northern European cohorts are shown.
| Characteristic | Birmingham | Northern Europe | p value |
|---|---|---|---|
| Number of patients | 187 | 589 | |
| Age, years | 67 (56-77) | 63 (52-71) | <0.0011 |
| Age at diagnosis, years | 58 (46-68) | 54 (42-63) | 0.0031 |
| Male (%) | 104 (56) | 302 (51) | 0.3142 |
| Genotype | |||
| AA (%) | 23 (12) | 30 (5) | 0.0012 |
| AC (%) | 72 (39) | 231 (39) | 0.9322 |
| CC (%) | 92 (49) | 328 (56) | 0.1302 |
| Granulomatosis with polyangiitis (%) | 110 (59) | 531 (90) | <0.0012 |
| Microscopic polyangiitis (%) | 77 (41) | 58 (10) | <0.0012 |
| Age at diagnosis, years | 58 (46-68) | 54 (42-63) | 0.0031 |
| Creatinine at presentation, µmol/L | 182 (100-385) | 90 (90-150) | <0.0011 |
| Cytoplasmic (c) ANCA (%) | 109 (58) | Not measured | |
| Perinuclear (p) ANCA (%) | 71 (38) | Not measured | |
| Proteinase 3 (PR3) (%) | Not measured | 438 (74) | |
| Myeloperoxidase (MPO) (%) | Not measured | 97 (17) | |
| Negative (%) | 7 (4) | 54 (9) |
1 Mann-Whitney U test
2 Fisher’s exact test