Table 2. Multivariate regression analysis of genotypes non-CC vs. CC for CAV1 SNP rs4730751.
| Variable | HR | 95% Confidence Interval | p value |
|---|---|---|---|
| Birmingham Cohort | |||
| Time to All-cause mortality | 1.83 | 1.02-3.27 | 0.042 |
| Time to Death from Vascular cause | 3.13 | 1.07-9.10 | 0.037 |
| Time to Death from Infection | 3.71 | 1.28-10.77 | 0.016 |
| Time to Cancer Development from AAV diagnosis | 5.55 | 1.59-19.31 | 0.007 |
| Time to Renal Replacement Therapy | 1.79 | 0.86-3.73 | 0.119 |
| Northern Europe Cohort | |||
| Time to All-cause mortality | 0.90 | 0.44-1.84 | 0.764 |
| Time to Death from Vascular cause | 1.33 | 0.27-6.67 | 0.729 |
| Time to Death from Infection | 0.24 | 0.28-2.00 | 0.196 |
| Cancer | 0.77* | 0.28-2.17 | 0.625 |
| Time to Renal Replacement Therapy | 1.37 | 0.63-2.96 | 0.427 |
Times to event endpoint for both cohorts were adjusted for age at diagnosis, gender, creatinine at presentation and type of ANCA.
* Exact date of cancer onset during follow-up period not available, thus logistic regression analysis used, expressed as Odds Ratio