Table 3. Cox regression analyses assessing the association of genotype upon the outcomes when the cohort is divided into diagnoses and then an assessment of the significance of interaction to address if the CAV1 SNP genotype effect varied between diagnoses.
| Time to Event | Diagnosis | Hazard Ratio (95% CI) | CC vs. non-CC P-value | Interaction P-value |
|---|---|---|---|---|
| All-cause mortality or RRT | GPA | 0.56 (0.36, 0.86) | 0.009 | 0.66 |
| MPA | 0.67 (0.39, 1.15) | 0.15 | ||
| All-cause mortality | GPA | 0.74 (0.43, 1.29) | 0.29 | 0.25 |
| MPA | 0.47 (0.25, 0.90) | 0.02 | ||
| Death from vascular cause | GPA | 0.33 (0.11, 1.04) | 0.06 | 0.95 |
| MPA | 0.33 (0.10, 1.06) | 0.06 | ||
| Death from infection | GPA | 0.63 (0.24, 1.66) | 0.35 | 0.49 |
| MPA | 0.40 (0.15, 1.09) | 0.07 | ||
| Cancer *) | GPA | 0.18 (0.04, 0.82) | 0.03 | 0.62 |
| MPA | 0.11 (0.01, 0.87) | 0.04 | ||
| Renal Replacement Therapy | GPA | 0.39 (0.20, 0.76) | 0.006 | 0.04 |
| MPA | 1.16 (0.54, 2.51) | 0.70 |
* Analysis performed on Birmingham data only, as time to cancer data was unavailable for the Northern European cohort.