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Significantly increased antibody staining of Ddr2, Mmp13, HtrA1 in Dmm/+ mice. Significant staining of OA biomarkers HtrA1 (B,A); Ddr2 (D,C) and Mmp13 (F,E) was observed in Dmm/+ compared to six month, aged matched, wildtype mice respectively (p< 0.01). This suggests that the Ddr2 degradative pathway plays an active role in the articular cartilage of Dmm/+ mice. Insets show virtually no staining in WT mice and greatly increased staining of biomarkers in Dmm/+.
