Table 2.

Activation to cocaine versus neutral cues across participants

Contrast	Cluster	Z Max	P	Voxel	MNI (x, y, z)	Anatomy
Cocaine > Neutral	1	5.89	< .001	1700	−36, −85, −4	L lateral occipital cortex, inferior (BA 18)
		5.81			−30, −94, −1	L occipital pole
		5.67			−39, −64, −7	L cerebral white matter
	2	5.87	< .001	2219	−24, 44, 41	L frontal pole
		5.81			−9, 62, 23	L frontal pole
		5.17			−12, 41, 50	L cerebral cortex
	3	5.59	< .001	343	−42, 35, 11	L inferior frontal gyrus, pars triangularis
		4.55			−39, 41, 2	L cerebral white matter
		4.52			−30, 29, −16	L frontal orbital cortex
	4	5.56	< .001	1706	30, −82, 5	R cerebral white matter
		5.47			33, −94, 5	R occipital pole
		5.43			30, −82, 23	R lateral occipital cortex, superior
	5	5.11	< .001	699	42, 8, 29	R precentral gyrus (BA 9)
		4.88			42, 38, 8	R frontal pole
		4.83			57, 14, 35	R precentral gyrus (BA 9)
	6	4.56	< .001	222	9, 14, −4	R nucleus accumbens
		4.36			9, 11, 5	R caudate
		4.28			18, −1, 20	R caudate
	7	4.23	< .001	289	−21, −16, −13	L hippocampus
		4.11			−3, −22, −13	brainstem
		3.89			−12, −31, −7	brainstem
	8	4.03	.013	79	−3, −52, 26	cingulate gyrus, posterior
	9	3.82	.012	80	51, −34, 50	R supramarginal gyrus, anterior

Note: Analyses (one-sample t-test) completed using cluster thresholding (z > 3.50 and corrected cluster threshold of p < .05). Anatomy = most probable region identified using the Harvard-Oxford cortical and subcortical structural atlases; Brodmann areas (where available) identified by the Talairach-Tournoux Atlas. Z Max = local maximum z-value, MNI (x, y, z) = Montreal Neurological Institute coordinates for the local maximum, BA = Brodmann Area.