Table 3.
Activation to cocaine versus neutral cues post-study versus pre-study
| Contrast | Cluster | Z Max | P | Voxel | MNI (x, y, z) | Anatomy |
|---|---|---|---|---|---|---|
| Pre-study > Post-study |
1 | 5.05 | < .001 | 341 | 6, 14, −1 | R nucleus accumbens |
| 4.60 | −6, 17, −1 | L nucleus accumbens | ||||
| 4.18 | −3, 8, −7 | L cerebral cortex (BA 25) | ||||
| 2 | 4.68 | < .001 | 1302 | −24, 41, 41 | L frontal pole | |
| 4.56 | 18, 29, 41 | R cerebral white matter | ||||
| 4.36 | −15, 35, 53 | L superior frontal gyrus | ||||
| 3 | 4.18 | .036 | 70 | −39, 14, 41 | L middle frontal gyrus | |
| 4 | 4.13 | .003 | 163 | 48, −13, −16 | R insular cortex | |
| 4.11 | 33, −22, 5 | R insular cortex | ||||
| 4.06 | 33, −16, −7 | R cerebral white matter | ||||
| 5 | 4.00 | .009 | 120 | 45, 44, 8 | R frontal pole (BA 10) | |
| 3.92 | 54, 23, 5 | R inferior frontal gyrus | ||||
| 3.71 | 57, 26, 14 | R inferior frontal gyrus | ||||
| 6 | 3.85 | .040 | 67 | −45, −40, 5 | L cerebral white matter | |
| 3.42 | −48, −52, −1 | L cerebral white matter | ||||
| 3.40 | −54, −37, 2 | L middle temporal gyrus, posterior |
Note: Analyses (within-subjects main effect of MRI session from 2×2 mixed effects ANOVA) completed using cluster thresholding (z > 3.32 and corrected cluster threshold of p < .05). Anatomy = most probable region identified using the Harvard-Oxford cortical and subcortical structural atlases; Brodmann areas (where available) identified by the Talairach-Tournoux Atlas. Z Max = local maximum z-value, P = cluster-level p value, MNI (x, y, z) = Montreal Neurological Institute coordinates for the local maximum, BA = Brodmann Area.