Figure 4.

Transcriptional regulatory network showing interactions between differentially expressed ROS + proteins and androgen receptor. Proteins with red or blue circles around them are over-expressed (HSPA5 and TGM4) or underexpressed (PRDX6) in spermatozoa from the ROS + (relative to ROS-) group. The levels of expression values are reflected in the intensity of red or blue colors. Green arrows with a hexagon indicate positive effect. TR = Transcription regulation; PGK2 = phosphoglycerate kinase 2; GAPD-S = glyceraldehyde phosphate dehydrogenase-S; GAPDH = glyceraldehyde-3-phosphate dehydrogenase; ALDOA = fructose-biphosphate aldolase A; and MDH2 = mitochondrial malate dehydrogenase precursor.