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. 2013 Jul 1;13:70. doi: 10.1186/1471-2377-13-70

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Copyright © 2013 Raz et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ECM down-regulation in OPMD patients. A. Gene ontology trees of the extracellular region component and binding molecular function of ECM localized components are significantly deregulated in the human OPMD transcriptome. P-values indicated for each GO-term were calculated by Global test. Between hyphens the numbers of deregulated genes (left) and the total number of annotated genes per GO-term (right) are indicated. B. ECM and Collagen encoding genes are predominantly deregulated in OPMD. Histogram shows the percentage of up-regulated and down-regulated genes in the ECM and Collagen GO categories.