Table 5.
PK parameters of ciprofloxacin in grass carp (n = 5)
|
Tissues Parameter |
Dose |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
10 mg/kg |
20 mg/kg |
30 mg/kg |
||||||||||
| Serum | Liver | Muscle | Kidney | Serum | Liver | Muscle | Kidney | Serum | Liver | Muscle | Kidney | |
| A(μg/mL) |
0.104 |
0.172 |
0.048 |
0.118 |
0.169 |
0.435 |
0.185 |
0.21 |
0.203 |
0.687 |
0.254 |
0.453 |
| A(/h) |
0.01 |
0.008 |
0.001 |
0.011 |
0.009 |
0.008 |
0.003 |
0.012 |
0.007 |
0.007 |
0.005 |
0.015 |
| Ka(/h) |
0.078 |
0.249 |
0.171 |
0.202 |
0.268 |
0.222 |
0.171 |
0.214 |
0.248 |
0.217 |
0.222 |
0.211 |
| Kel(/h) |
0.031 |
0.027 |
0.016 |
0.019 |
0.02 |
0.028 |
0.012 |
0.022 |
0.019 |
0.025 |
0.012 |
0.023 |
| T1/2α(h) |
70.300 |
54.558 |
126.553 |
46.273 |
74.727 |
74.283 |
129.297 |
57.892 |
92.733 |
98.544 |
140.684 |
63.202 |
| Tmax(h) |
6.000 |
1.000 |
48.000 |
6.000 |
1.000 |
0.500 |
10.000 |
2.000 |
0.500 |
0.500 |
4.000 |
1.000 |
| Cmax(μg/mL) |
0.187 |
0.759 |
0.233 |
0.188 |
0.225 |
1.219 |
0.276 |
0.348 |
0.254 |
1.480 |
0.329 |
0.386 |
| MRT0-t(h) |
61.453 |
61.61 |
60.652 |
59.982 |
64.912 |
62.200 |
71.581 |
63.192 |
69.093 |
67.674 |
73.703 |
64.946 |
| AUC(μg/mL·h) |
8.392 |
17.09 |
2.704 |
7.633 |
13.516 |
29.941 |
21.380 |
12.166 |
17.665 |
55.732 |
26.675 |
18.329 |
| CLs(L/kg·h) | 0.920 | 0.429 | 17.893 | 0.913 | 1.078 | 0.214 | 0.272 | 0.572 | 1.072 | 0.102 | 0.210 | 0.331 |
A(μg/mL), Intercept of the linear equation on log transformed data; α(/h), Distribution rate constant; Ka(/h), Absorption rate constant; Kel(/h), elimination rate constant from the central compartment; T1/2α(h), Half-life of distribution; Tmax(h), Time required to reach Cmax in the interval; Cmax(μg/mL), Maximum concentration in the interval; MRT0-t(h), Mean residue time of drug in body from zero to 168h; AUC(μg/mL·h), Area under the drug concentration-time curve from the time zero to last time point; CLs(L/kg·h), total body clearance.