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. 2013 Jun 27;6:43. doi: 10.1186/1756-8722-6-43

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Copyright © 2013 Chen et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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L1cam promotes cell proliferation, migration and invasion in gastric cancer cell lines. (A) L1cam protein level is increased after over-expression of L1cam in HGC27 cells and decreased after knockdown of L1cam in SGC7901 cells. (B) and (C) Ectopic expression of L1cam stimulates cell proliferation in HGC27 cells whereas knockdown of L1cam inhibits cell proliferation in SGC7901 cells as determined by MTT assays (B) and colony formation assays (C). (D) and (E) Ectopic expression of L1cam stimulates cell motility whereas knockdown of L1cam inhibits cell motility in gastric cancer cells as determined by migration assays (D) and invasion assays (E). Bars represented mean ± SD of three independent tests, all *P < 0.05.