Figure 5.

Fluid diagram for each unit operation. (a) Side profile schematic of the disposable cassette. The remaining figures show the schematic of cassette fluid paths for each unit operation. (b) Evaporate. Gas supplier provides vacuum and inert gas flow while the reactor is heated. (c) React1. First fully sealed reaction position. (d) React2. Second fully sealed reaction position. (e) Add. Vial gripper presses a reagent vial into one of two addition positions where two needles pierce the vial's septum; one needle allows inert gas flow from the gas supplier through the inert gas port, and the other needle allows the reagent to flow into the reaction vessel. (f) Transfer. Contents of one reaction vessel can be transferred to another cassette, the HPLC valve, or to a purification cartridge. (g) Radioisotope handling. [¹⁸F]fluoride trap and release can be done using two of the built in stopcock valves.