Table 2.

Pharmacokinetic parameter estimates and standard errors of the model

Parameter	Estimate (95 % CI), outlier concentrations excluded	Estimate (95 % CI), outlier concentrations included
Clearance (L/h)	39 (37–41)	38 (36–40)
Between-subject variability of clearance (%)	62 (52–72)	67.6 (40–95)
Volume of distribution (L)	104 (93–115)	108 (38–177)
Between-subject variability of volume of distribution (%)	57 (13–100)	64.7 (0–129)
Residual error, additive (ng/mL)	0.086 (0.067–0.10)	0.086 (0.054–0.12)
Residual error, proportional (%)	32.6 (32.0–33.2)	38.7 (−6 to 83)