Fig. 1.

Alignments of templates to target structure. Alignment of templates for homology modeling labeled by their PDB entry code to the target sequence of the human M₂ muscarinic acetylcholine receptor. Stars denote conserved and dots consensual residues. Colors denote secondary structure: red—helix; white—coil; yellow—strand; green—turn. Secondary structure of the target was predicted by PsiPred (http://bioinf.cs.ucl.ac.uk/psipred/) and secondary structures of templates were taken from respective crystal structures. For orientation transmembrane (TM) helices, inner (i) and outer (o) loops are indicated