Table 4.
Analysis of homology models for major intramolecular interactions stabilizing muscarinic receptors
| ver01 | ver02 | ver03 | ver04 | ver05 | ver06 | ver07 | ver08 | ver09 | ver10 | ver11 | ver12 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TM II–TM IV | ||||||||||||
| Ser64–Asn113 | Y | Y | Y | N | Y | N | Y | Y | N | N | N | N |
| Ser64–Trp148 | Y | Y | Y | Y | N | Y | Y | Y | N | N | N | N |
| TM II–TM VII | ||||||||||||
| Asp69–Ser433 | Tyr440 | Y | Y | N | Y | Tyr440 | Y | Y | N | N | N | N |
| Asp69–Asn436 | Y | Y | Y | Y | Y | Y | Tyr440 | Y | Y | Tyr440 | Y | N |
| TM III–o2 | ||||||||||||
| Asp97–Gln163 | N | N | N | N | N | Y | Y | Y | Y | N | N | N |
| Asp97–Arg169 | N | N | Y | N | N | Gln179 | Y | Y | Y | N | N | N |
| TM III–TM IV | ||||||||||||
| Asn108–Ser151 | Thr190 | N | Y | N | Y | N | Y | Y | N | N | Y | Y |
| Asn108–Trp155 | N | N | N | N | N | N | Y | N | N | N | N | N |
| TM III–TM VI | ||||||||||||
| Arg121–Glu382 | Ser118 | Asp120 | Y | Y | Asp120 | Y | Y | Y | N | N | N | Asp120 |
Existence of the hydrogen bond between amino acid pair shown in row at model shown in column is indicated as yes (Y), no (N) or interaction with alternative amino acid