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. 2012 Nov 20;31(4):910–917. doi: 10.1007/s10637-012-9895-6

Fig. 2.

Fig. 2

Ratio of free aflibercept concentration to VEGF-bound aflibercept concentration at the trough (2 weeks after aflibercept administration) across the treatment cycles for dose 2 (4.0 mg/kg). The mean ± SD value for each cycle is indicated. Note that the free/VEGF-bound aflibercept concentration ratio was maintained at >1 (dotted line) throughout the treatment duration