Fig. 2.
Ratio of free aflibercept concentration to VEGF-bound aflibercept concentration at the trough (2 weeks after aflibercept administration) across the treatment cycles for dose 2 (4.0 mg/kg). The mean ± SD value for each cycle is indicated. Note that the free/VEGF-bound aflibercept concentration ratio was maintained at >1 (dotted line) throughout the treatment duration