Table 2.

Incidence of common all-causality adverse events^a by worst grade

Preferred term	Dose level
	2 mg/kg (N = 3)		4 mg/kg (N = 13)
	All grades n (%)	Grades 3, 4 n (%)	All grades n (%)	Grades 3, 4 n (%)
Hematological toxicitiesb
Leukopenia	3 (100 %)	1 (33.3 %)	13 (100 %)	8 (61.5 %)
Neutropenia	3 (100 %)	3 (100 %)	12 (92.3 %)	10 (76.9 %)
Anemia	3 (100 %)	0	11 (84.6 %)	1 (7.7 %)
Thrombocytopenia	2 (66.7 %)	0	9 (69.2 %)	1 (7.7 %)
Non-hematological toxicities
Diarrhoea	3 (100 %)	0	12 (92.3 %)	1 (7.7 %)
Fatigue	3 (100 %)	0	12 (92.3 %)	0
Decreased appetite	2 (66.7 %)	0	12 (92.3 %)	0
Stomatitis	2 (66.7 %)	0	11 (84.6 %)	2 (15.4 %)
Dysphonia	2 (66.7 %)	0	11 (84.6 %)	0
Nausea	3 (100 %)	0	11 (84.6 %)	0
Epistaxis	1 (33.3 %)	0	10 (76.9 %)	0
Hypertension	0	0	8 (61.5 %)	4 (30.8 %)
Alopecia	2 (66.7 %)	0	8 (61.5 %)	0
Vomiting	3 (100 %)	0	7 (53.8 %)	0
Headache	1 (33.3 %)	0	6 (46.2 %)	0
Nasopharyngitis	1 (33.3 %)	0	5 (38.5 %)	0
Abdominal pain	1 (33.3 %)	0	5 (38.5 %)	0
Constipation	0	0	5 (38.5 %)	0
Gingivitis	0	0	5 (38.5 %)	0
Pyrexia	1 (33.3 %)	0	4 (30.8 %)	0

^aEvents listed are those occurring in ≥4 patients at 4 mg/kg at any grade.

^bBased on laboratory data.