Table 3.

AUC Venous Minus AUC Arterial (Delta AUC) of the Measured Plasma Biomarkers for Oxidative and Nitrosative Damage During the Early Reperfusion Phase (p Values)

	Kidney transplantation			Cardiac valve surgery
Delta AUCa	LD	DD	LD urineb	Heart failure	No heart failure
Oxidative damage
Malondialdehyde (nM×min)	138.2	Not measured		−4544	1758
(p value)	(0.17)		(0.40)	(0.05)	(0.43)
15(S)-8-iso-PGF2α (pM×min)	356	−1306		1056	934
(p value)	(0.03c)	(0.16)	(0.35)	(0.02c)	(0.18)
Nitrosative stress and damage
Nitrite (nM×min)	308	−910		−6949	−5878
(p value)	(0.50)	(0.87)	(0.06)	(0.002)	(0.03)
Nitrate (μM×min)	−36	77		−14	75
(p value)	(0.50)	(0.98)	(0.69)	(0.53)	(0.81)
Nitrotyrosine (nM×min)	−113	Not measured	Not measured	Not measured	Not measured
(p value)	(0.93)

^aDelta AUC: AUC venous minus AUC arterial (p value) of the measured plasma markers during the early reperfusion phase. A positive number indicates a release from the reperfused organ, whereas a negative number indicates an uptake of the biomarker.

^bResults in urine indicate p-values of the difference of the pre- and postreperfusion measure.

^cSignificant venous release (p<0.05).

AUC, area under the curve.