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. 2013 Apr 22;591(Pt 13):3253–3269. doi: 10.1113/jphysiol.2013.254367

Figure 7. VDF is weaker in dfcr compared to control IHCs after hearing onset in mice.

Figure 7

A, measurement of VDF onset. Left, voltage protocol and representative current traces obtained with indicated prepulse durations. P1 and P2 currents are overlaid for comparison. Right, P2/P1 ratios were expressed as percentage of the maximal VDF obtained with a 165 ms prepulse and plotted against prepulse duration. Smooth line represents single-exponential fit. The mean time constant (±SEM) is indicated. B and C, top, voltage protocol for IHC VDF showing 20 ms test pulses (P1, P2) from −75 to −15 mV separated by a 50 ms prepulse to various voltages. Representative traces for IBa obtained with +50 mV prepulse for IHCs from postnatal days (p) 16–18 (B) or p6–8 (C) control (n= 25 for p16–18, n= 18 for p6–8) or dfcr (n= 26 for p16–18, n= 18 for p6–8) mice. Dashed line represents initial amplitude of P1 current. Bottom, Fratio was calculated as P2 divided by P1 current amplitude and plotted against prepulse voltage.