Table 1. Relative expression of genes related to tumor growth.
| Gene | D-Trp6-LHRH | DOX | D-Trp6 + DOX | AN-152 |
|---|---|---|---|---|
| Angiopoietin 1 | 0.71 | 0.51 | 0.65 | 0.2 |
| Insulin-like growth factor 1 | 0.33 | 0.5 | 0.22 | 0.08 |
| Integrin, α4 (α4 subunit of VCAM-1 receptor) | 0.25 | 0.33 | 0.59 | 0.46* |
| Integrin, αV (domain of vitronectin receptors) | 0.25* | 0.38 | 0.57 | 0.32* |
| Integrin, β5 (domain of vitronectin receptor) | 1.14 | 1.3 | 0.84 | 0.46* |
| Mitogen-activated protein kinase 1 | 0.65* | 1 | 0.19 | 0.22 |
| Melanoma cell adhesion molecule | 0.24* | 0.57 | 0.19 | 0.06* |
| Matrix metalloproteinase 9 (gelatinase B) | 0.34 | 0.73 | 0.5 | 0.2* |
| Metastasis associated 1 family, member 2 | 0.6 | 1.02 | 1.2 | 0.68* |
| Nuclear factor κB | 0.85 | 1.13 | 0.11* | 0.6* |
| Phosphoinositide-3-kinase, regulatory subunit 1α | 0.49* | 0.74 | 0.67 | 0.67* |
| Plasminogen activator (urokinase) | 1.34 | 1.79* | 0.8 | 0.6* |
| Platelet-derived growth factor α | 0.83 | 1.52 | 4.09 | 0.36* |
| Serpin, clade B, member 5 (maspin) | 0.16 | 0.14 | 17.67* | 4.27 |
| Tumor necrosis factor receptor superfamily, 10β | 0.84 | 1.63 | 1.14 | 1.87* |
| V-raf-1 murine leukemia viral oncogene homolog 1 | 0.74 | 1.06 | 1.13 | 0.63* |
In vivo glioblastoma specimens were evaluated by Cancer Pathway RT2 Profiler PCR Array system. Only genes with at least three-fold or statistically significant changes are represented. Four tumor samples from each group were analyzed. Relative expressions are compared to the control. *p < 0.05 vs. control. Abbreviations: DOX: doxorubicin, D-Trp6 + DOX: D-Trp6-LHRH + doxorubicin, VCAM: vascular cell adhesion molecule.