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. 2013 Mar 23;4(3):463–473. doi: 10.18632/oncotarget.886

Figure 2. siRNA against IGF-1R, SGLT, and GLUT decrease intracellular glucose levels, but OSI-906 does not.

Figure 2

(a) IGF-1R, SGLT, and GLUT siRNA significantly decreased intracellular glucose levels in HEK293 cells cultured in low/physiologic (5mM) glucose DMEM, but not in high (25 mM) glucose DMEM. (b) IGF-1R, SGLT, and GLUT siRNA significantly decreased intracellular glucose levels in MCF7 cells cultured in low glucose, and to a lesser extent in high glucose. (c) Intracellular glucose levels were not significantly affected by OSI-906 (10-50 nM) in either cell line in low, medium (17 mM), or high (25 mM) glucose DMEM. All experiments were repeated at least three times and significance determined by student's t test.