TABLE 3.

Cardiovascular Response to Oral Rimonabant in 10 Daily Cannabis Smokers

	Time Point
		Day 9																Day 10
ID	Vitals Measure	8:00 a.m.	9:30 a.m.	10:00 a.m.	10:30 a.m.	11:00 a.m.	11:30 a.m.	Noon	12:30 p.m.	1:30 p.m.	2:30 p.m.	3:30 p.m.	4:00 p.m.	4:30 p.m.	5:30 p.m.	6:30 p.m.	11:00 p.m.	8:00 a.m.
1	Systolic BP	109	110	115	126	107	109	111	124	130	139	141	121	130	124	136	122	118
	Diastolic BP	65	62	63	52	52	53	64	59	83	86	64	70	85	63	82	76	67
	Heart rate	66	60	89	62	60	58	66	62	72	88	73	69	79	70	76	71	61
2	Systolic BP	120	130	119	122	126	130	121	127	140	128	143	136	132	120	128	140	129
	Diastolic BP	70	74	67	68	70	77	69	77	70	77	81	76	71	74	77	84	77
	Heart rate	74	72	65	65	62	64	60	60	60	61	61	63	71	64	67	69	89
3	Systolic BP	119	999	118	126	137	140	152	141	138	147	999	136	148	130	134	135	124
	Diastolic BP	64	999	56	59	62	60	61	62	55	69	999	59	64	57	73	69	64
	Heart rate	65	999	71	68	71	70	64	65	90	68	999	71	78	71	68	71	66
4	Systolic BP	106	999	109	112	110	110	118	116	122	119	123	129	124	116	112	125	127
	Diastolic BP	50	999	55	64	54	52	54	52	65	61	71	53	65	60	66	60	77
	Heart rate	73	999	66	68	70	63	70	62	88	79	65	68	70	67	67	68	70
5	Systolic BP	109	999	98	91	100	102	102	105	113	112	118	116	117	116	118	111	106
	Diastolic BP	67	999	58	51	51	51	55	58	68	72	61	61	62	76	76	68	71
	Heart rate	65	999	74	61	71	65	61	60	68	68	60	64	62	89	66	91	70
6	Systolic BP	111	999	109	111	111	109	112	103	119	122	104	114	110	113	124	117	113
	Diastolic BP	55	999	55	55	54	62	55	56	67	62	55	54	64	62	66	60	67
	Heart rate	70	999	65	71	70	65	66	63	74	62	66	69	59	73	65	68	67
10	Systolic BP	132	131	133	142	148	145	132	130	139	149	140	150	131	140	144	147	132
	Diastolic BP	78	66	73	73	73	74	73	63	80	71	70	71	74	75	79	72	69
	Heart rate	66	73	69	61	66	72	85	71	81	81	92	105	71	106	77	99	80
11	Systolic BP	126	124	124	147	138	153	131	144	148	144	149	148	126	138	151	134	135
	Diastolic BP	81	87	75	81	78	90	79	75	88	88	89	82	89	76	79	80	86
	Heart rate	89	75	78	85	98	84	89	83	88	93	80	113	91	92	93	93	83
12	Systolic BP	123	123	140	140	127	120	123	135	128	143	129	142	137	144	151	130	140
	Diastolic BP	66	53	61	61	50	51	60	61	57	63	58	58	62	70	67	63	76
	Heart rate	58	57	54	58	61	56	60	55	58	57	56	71	83	86	93	93	58
13	Systolic BP	104	98	120	109	122	123	111	116	121	132	134	145	125	128	127	131	117
	Diastolic BP	57	51	66	56	51	65	54	54	63	84	71	67	68	60	69	67	62
	Heart rate	62	64	65	54	63	78	68	67	68	57	59	64	64	70	59	73	55

Rimonabant 20 mg (subjects 1, 2, 3, 5, and 6), 40 mg (subjects 10, 11, and 13), or placebo (subjects 4 and 12) was given double-blind at 9:30 a.m. on day 9 after 8 days of escalating doses of oral dronabinol (40–120 mg/d). Systolic and diastolic blood pressure (BP; mm Hg) and heart rate (beats per minute) were assessed at the indicated time points. See text for methodological details.