Table 4.
Extraction efficiency, process efficiency and matrix effect
| Analyte | Extraction efficiency (n=5) |
Process efficiency (n=5) |
Matrix effect (CV%) (n=10) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Low | Medium | High | Low | Medium | High | Low | Medium | High | |
| EME | 56.9 | 70.8 | 160.9 | 28.3 | 37.2 | 52.6 | −53.3 (13.9) | −63.3 (51.7) | −63.3 (29.3) |
| BE | 35.3 | 36.9 | 46.7 | 41.3 | 38.6 | 43.8 | 14.8 (2.7) | 2.8 (3.0) | −7.7 (2.3) |
| Cocaine | 38.8 | 45.8 | 47.7 | 32.5 | 42.3 | 46.7 | −14.1 (4.5) | −9.3 (3.4) | −3.7 (2.9) |
| Morphine | 40.6 | 45.0 | 42.2 | 32.4 | 40.8 | 40.6 | −19.2 (6.9) | −11.9 (5.8) | −6.0 (3.1) |
| Codeine | 42.8 | 46.4 | 48.7 | 42.9 | 43.2 | 46.6 | 1.8 (3.3) | −8.4 (3.7) | −6.4 (3.4) |
| 6AM | 37.3 | 41.8 | 44.7 | 38.0 | 40.3 | 46.4 | 4.7 (4.7) | −5.6 (7.4) | 1.8 (3.5) |
| 6AC | 38.5 | 46.1 | 51.2 | 35.5 | 42.2 | 49.4 | −8.2 (3.4) | −9.7 (3.4) | −5.5 (3.0) |
| Heroin | 46.2 | 53.6 | 54.7 | 54.4 | 51.7 | 48.9 | 16.1 (5.6) | −6.3 (9.3) | −12.4 (3.7) |
| Cotinine | 49.1 | 50.9 | 50.6 | 49.3 | 51.9 | 53.3 | 5.6 (8.1) | −3.8 (7.6) | 4.4 (3.2) |
| OH-Cotinine | 39.2 | 45.6 | 45.7 | 37.4 | 45.4 | 44.7 | −4.3 (3.0) | 0.02 (2.6) | −3.6 (2.7) |
| Methadone | 54.5 | 54.1 | 58.4 | 46.2 | 56.3 | 62.3 | −10.5 (9.8) | −0.6 (7.6) | 4.1 (6.6) |
| EDDP | 63.5 | 51.3 | 52.2 | 25.5 | 25.7 | 49.5 | −56.5 (21.2) | −60.4 (36.0) | −9.5 (7.6) |
| BUP | 40.4 | 46.0 | 47.9 | 45.2 | 47.5 | 49.6 | 12.7 (2.4) | 1.5 (2.9) | 0.3 (4.5) |
| NBUP | 65.4 | 54.4 | 52.8 | 91.7 | 55.7 | 50.5 | 42.6 (4.2) | −2.1 (7.5) | −7.0 (4.3) |