FIGURE 2.
The association between plasma rimonabant concentrations and change from baseline plasma cortisol concentrations up to 12.5 hours after 20 or 40 mg rimonabant. Eight daily cannabis smokers were administered 20 mg Δ9-tetrahydrocannabinol (THC) orally every 4–8 hours for 8 days. On the ninth day, baseline cortisol concentrations were obtained at 08:00 and subjects received oral rimonabant at 09:30 concurrently with the last dose of THC. Line shows least squares linear regression best fit to all rimonabant concentrations.