TABLE 1.

Plasma rimonabant concentrations following a single 20 or 40 mg rimonabant dose in eight daily cannabis smokers.

Rimonabant concentration (ng/mL)
Subject	Dose	Time of sample
		11:30	15:00	22:00
A	20	89.5	76.2	49.1
B	20	181	67.0	23.6
C	20	71.8	33.2	10.7
D	20	172	54.7	27.6
E	20	168	61.4	44.8
F	40	378	111	45.0
G	40	143	67.7	23.5
H	40	187	57.2	30.3

Note: Daily cannabis smokers were administered Δ9-tetrahydrocannabinol (THC) 20 mg orally every 4–8 hours over 8 days (120 mg THC/day for last 3 days prior to rimonabant). At 9:30 on the ninth day, five subjects received rimonabant 20 mg and three subjects received rimonabant 40 mg concurrently with the last dose of THC.