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Doses of MTM and its analogs (SDK and SK) that promote protection in immature primary cortical neurons induce cell death in transformed SH-SY5Y neuroblastoma cells. As expected, SDK was more effective in inducing cell death than MTM or SK. PreB did not induce cell death in neuroblastoma cells, further suggesting that the DNA binding ability of these compounds is necessary for their function. **p < 0.01; ***p < 0.0001.
