Figure 6.

A network of genes centered on Myc covaries with MTM-mediated neuroprotection in immature primary cortical neurons (E17). A, Protective doses of MTM (300 nm) and SDK (75 nm) induce significant changes in gene expression compared with HCA (5 mm) alone or with nonprotective doses of MTM (50 nm), SDK (7.5 nm), or PreB (300 nm). Cells were treated with the compounds for 4 h. B, DE genes are highly overlapping after treatment with protective doses of MTM and SDK. C, Ingenuity analysis reveals a network of genes centered on Myc and whose expression covaries with protection by MTM and its analogs.