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. Author manuscript; available in PMC: 2013 Aug 17.
Published in final edited form as: Annu Rev Cell Dev Biol. 2012 Aug 17;28:163–187. doi: 10.1146/annurev-cellbio-101011-155824

Figure 2.

Figure 2

Structure of some of the domains created by interactions between CTCF insulators in mouse embryonic stem cells. Actively transcribed genes are represented by a green arrow and silenced genes by a red line; nucleosomes and the histone tails are represented in grey, with active histone modifications indicated as green spheres and repressive modifications as red spheres. DNA is represented in black and CTCF as blue ovals. A. CTCF forms a loop to separate a domain containing active histone modifications and transcribed genes from repressive marks and silenced genes. B. CTCF forms a loop to separate a domain containing repressive histone modifications and silenced genes from active marks and transcribed genes. C. CTCF forms a loop containing nucleosomes enriched in mono and dimethylated H3K4, and trimethylated H3K4 at the boundaries of the loops, whereas the active transcription modification H3K36me3 and repressive H3K27me3 mark are observed outside the loops on opposite sides.