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Cross-pharmacology profiles among (a) GPCR and (b) non-GPCR targets for the adenosine 2B receptor (ADORA2B). All numerical bioactivity data available (pKi, pIC50, and pEC50) were considered and the criteria for shared ligands were set to d ≤ 0.2 and pAct ≥ 7.0. See text for the definition of the different parameters (Li, Ti, Ei, Bi and Le, Te, Ee, Be). Description of gene names is available as Supplementary Material.
