Table 1.
Crude Accelerators |
95%CI | p-value† | Adjusted Accelerators |
95%CI | p-value† | |
---|---|---|---|---|---|---|
Age category at start of TB treatment | 0.008 | |||||
≥ 40 (baseline) | 1 | |||||
25-39 | 1.12 | 1.04 - 1.21 | 0.003 | |||
18-24 | 1.15 | 1.02 - 1.30 | 0.022 | |||
Gender | ||||||
Male | 1 | |||||
Female (baseline) | 1.01 | 0.94 - 1.07 | 0.879 | |||
Clinic | <0.001 | <0.001 | ||||
2 (baseline) | 1 | 1 | ||||
1 | 1.08 | 1.00 - 1.15 | 0.046 | 1.39 | 1.29 - 1.48 | <0.001 |
3 | 1.34 | 1.21 - 1.48 | <0.001 | 1.56 | 1.42 - 1.71 | <0.001 |
Year started TB treatment | <0.001 | <0.001 | ||||
2002-2004 (baseline) | 1 | 1 | ||||
2005 | 1.08 | 0.98 - 1.18 | 0.111 | 1.08 | 0.99 - 1.19 | 0.079 |
2006 | 1.34 | 1.23 - 1.46 | <0.001 | 1.22 | 1.12 - 1.33 | <0.001 |
2007-2008 | 1.83 | 1.65 - 2.03 | <0.001 | 1.39 | 1.25 - 1.54 | <0.001 |
CD4 count categories* (cells/μL) | <0.001 | <0.001 | ||||
>=200 (baseline) | 1 | 1 | ||||
100-199 | 1.16 | 1.03 - 1.32 | 0.017 | 1.20 | 1.07 - 1.34 | 0.002 |
50-99 | 1.29 | 1.14 - 1.47 | <0.001 | 1.34 | 1.19 - 1.50 | <0.001 |
0-49 | 1.70 | 1.49 - 1.94 | <0.001 | 1.75 | 1.55 - 1.98 | <0.001 |
Classification of TB | ||||||
Rtetreatment (baseline) | 1 | |||||
New TB case | 1.11 | 1.03 - 1.19 | 0.004 | |||
Type of TB | 0.018 | |||||
Smear-Negative Pulmonary TB (baseline) | 1 | |||||
Extra-Pulmonary TB | 1.05 | 0.97 - 1.13 | 0.262 | |||
Smear-Pbstive Pulmonary TB | 1.12 | 1.04 - 1.22 | 0.005 |
The p-value in line with the heading of each variable with more than 2 categories wascalculated using the Waid Test
CD4 count taken closest start of TB treatment that satisfied criteria of being taken not earlier than 183 daysbefore or 91 daysafter start of TB treatment and not more than 7 days after start of ART
Shape parametersof multivariate gamma model: kappa = 0.7 (95%CI: 0.57-0.84); sigma = 0.42 (95%CI: 0.39-0.45) for all strata other than CD4count lessthan 50 cells/μL(sgma = 0.59, 95%CI:0.50-0.69) and clinic 1 (sigma = 0.51, 95%CI: 0.44-0.60)