Table 5.

Inverse correlation with overall recovery across all patients

		Talairach coordinates in MNI space				Correlation analysis
Region	Side	x	y	z	Z	r 2	P
Central sulcus	IL	−54	−8	36	4.41	0.67	<0.0001
	CL	38	−26	52	4.02	0.6	0.0001
	CL	52	−12	40	4.22	0.64	<0.0001
Posterior central sulcus	IL	−38	−24	48	4.53	0.69	<0.0001
Postcentral gyrus	IL	−22	−42	66	4.59	0.70	<0.0001
	IL	−62	−20	30	4.25	0.64	<0.0001
Precentral gyrus (BA 4/6)	IL	−18	−18	64	4.16	0.63	<0.0001
PMd	IL	−24	−14	52	4.21	0.64	<0.0001
	CL	28	4	64	4.43	0.67	<0.0001
CCZ	CL	6	−8	52	4.98*	0.76	<0.0001
	IL	−8	2	62	4.73	0.72	<0.0001
RCZ	IL	−10	52	−4	3.89	0.58	0.0001
SMA	CL	4	−12	64	4.23	0.64	<0.0001
	IL	−2	−2	70	4.18	0.63	<0.0001
Pre-SMA	CL	8	20	52	4.55	0.69	<0.0001
Insula	CL	44	22	2	4.28	0.65	<0.0001
DLPFC	CL	34	34	28	4.03	0.60	0.0001
	IL	−34	34	20	4.01	0.60	0.0001
Cerebellum (CrI)	IL	−32	−76	−24	4.98*	0.76	<0.0001
Cerebellum (VIIB)	IL	−20	−66	−42	4.93	0.75	<0.0001
Cerebellum (VI)	IL	−26	−30	−32	5.11*	0.77	<0.0001
	CL	24	−62	−20	4.65	0.71	<0.0001
Cerebellar vermis	M	4	−62	−38	4.66	0.71	<0.0001

The table shows regions in which there was a negative correlation between recovery and task-related activation across all stroke patients. Coordinates represent peak voxels within significant cluster (P < 0.05, corrected for multiple comparisons across the whole brain volume).

^*Voxels significant at P < 0.05, corrected for multiple comparisons across the whole brain volume. The correlation coefficient (r²) and corresponding P value for the correlation analysis are also given. IL = ipsilateral; CL = contralateral; M = midline; BA = Brodmann area; CCZ = caudal cingulate sulcus; RCZ = rostral cingulate sulcus.