Table 1. List of predicted cancer drug targets.
| Cancer-related genes | Predicted target genes with empirical evidence: essential in cancer cell non-essential in normal cell | Novel predicted target genes: *unknown essentiality in normal cell and cancer cell **non-essential in normal cell and unknown essentiality in cancer cell |
|---|---|---|
| DDB2|FBXW7|EML4 | LSMD1 | PPIB|PPIC|PPID** |
| HDAC5|HDAC6 | NTG1|GNL3L|SSTR5** | |
| PPWD1|PPIH|PPIE | ||
| KIAA0564 | ||
| NSUN2|NSUN5 | ||
| BCL3|NOTCH2|CDKN2C|NFKB2 | HDAC5|HDAC6 | PPIB|PPIC|PPID** |
| PPWD1|PPIH|PPIE | ||
| MSI2 | DENR | |
| CREBBP|EP300|BRD4|PBRM1|BRD3|TRI-M24|SMARCA4 | USP12|USP22|USP30 | USP45** |
| PIK3CA | USP12|USP22|USP30 | USP45** |
| HDAC1 | TLE1 | |
| DDX5|DDX6|DDX10|EIF4A2 | ATAD2* | |
| PBRM1 | ACTG1 | |
| MED12 | MED14 | |
| HIST1H4I | H3F3A | |
| EZH2 | EED | |
| RPN1 | MAGT1 | |
| PIK3R1 | ESR1 | |
| SMAD4 | JUND | |
| CCNE1 | SKP1 | |
| CREBBP | KAT2B | |
| FANCF | C17orf70* | |
| FANCC | FANCB* | |
| FANCF | FANCB* | |
| SEPT9 | SEPT11** |
Twenty predicted cancer drug targets with experimental evidence (second column) and ten novel targets (third column). The grey-shaded rows show targets predicted by using orthology mapping and the rows without show targets predicted directly from human protein complexes. Each grey-shaded cell represents a Clusters of Orthologous Group (COG) of cancer-related genes or predicted drug targets. The first column shows the cancer-related genes. The second column shows 20 predicted drug targets with empirical evidence where each gene is essential in at least one cancer cell and non-essential in model organisms. The third column shows ten novel targets for which the essentiality in cancer cells has not yet been measured.