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. 2013 Mar 27;38(9):1698–1705. doi: 10.1038/npp.2013.68

Figure 3.

Figure 3

Effect of sex and estradiol on motivation for cocaine following extended access (ExA) self-administration. (a and c) Percent change in the number of infusions obtained following ExA self-administration relative to ShA control conditions. ((a) Female, filled bars; male, open bars; (c) Ovariectomized (OVX) + estradiol (E), filled bars; OVX + vehicle (Veh), open bars). *Significant difference from control; #Significant group difference (p<0.05). (b and d) Scatterplot of each individual rats data on percent change in the number of infusions obtained following ExA self-administration relative to ShA control conditions. ((b) Female, filled squares; male, open squares. (c) OVX+E, filled circles; OVX+Veh, open circles). Black solid bars represent the average values within each group, and dotted lines represent a 15% increase.